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generic ddavp nasal spray Mourinho used Ramires and Michael Essien together for the first time in the Premier League, presumably because that combination was considered most likely to take the ball past the Southampton press, but Essien's early error underlined his struggles, and Chelsea were unable to attack the Southampton defence throughout the opening period. The lack of passing quality in Chelsea's back four was also obvious ??? the injured David Luiz can be prone to defensive lapses, but he remains by far Chelsea's best distributor from deep positions.